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Hello inquisitive minds. The following is a site where you may discover basic information on the disease known as Huntington's Chorea. This disease has been in the forefront of medical genetic investigations. This is because of the devastating and delayed neurologic and psychatric effects of this disorder. It's manifestations usually present in adulthood with severe abnormalities in movement (chorea), dementia, and psychiatric disease. Such psychiatric symtoms include psychosis, depression, and suicidality. Another reason for such intense interest is due to it's inheritance pattern. Initially viewed as classically autosomal dominant, its variable penetrance (with different phenotypic expression) suggests a more complex situation. It has been determined that frequency of the CAG nucleotide repeats, due to shift mutation in chromosome 4, is the cause of such variability. The more the CAG repeats, the earlier the expression, and the more severe the disease. The incurable nature of this progressively deteriating condition so profoundly affects family members, as to force them to seek genetic counseling to prevent offspring from being afflicted. In the following pages, further explanations are provided.